SKU:80097821551
MOTS-c (10mg)
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Ships within 48 hours · Estimated delivery Jul 12 - Jul 17
Description
MOTS-c (10mg)Overview MOTS c (Mitochondrial Open Reading Frame of the 12S rRNA type c) is a 16 amino acid mitochondrial derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It translocates to the nucleus under metabolic stress and regulates genes involved in metabolism, inflammation, and stress resistance via the AMPK pathway. It is widely used in laboratory and preclinical research as a model compound to investigate mitochondrial nuclear
It is widely used in laboratory and preclinical research as a model compound to investigate mitochondrial-nuclear communication
inhibited leukocyte infiltration
Molecular Weight: ~76–80 kDa (dimer
Cellular Function
It functions as a soluble decoy receptor that binds myostatin (GDF-8) and other TGF-β superfamily ligands (activins
increased lipolysis
Cardiovascular and Renal Protection Research: In myocardial ischemia-reperfusion and acute kidney injury rodent models
Molecular Weight: 3108
PNC-27 is a 32-amino acid peptide featuring a p53-derived HDM-2 binding domain (residues 12-26) fused to a transmembrane-penetrating sequence
This property makes it a candidate for studies on overcoming drug resistance in cancer
Insulin Sensitivity: Through ERR pathway activation
Anti-Inflammatory and Vasoprotective Effects: Across multiple rodent inflammatory and ischemia-reperfusion models
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